Evidence supporting the use of: Ginsenosides (unspecified)
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ginsenosides are the primary active components of ginseng, particularly Panax ginseng, and have been studied for their effects on mitochondrial function. Preclinical studies (in vitro and animal models) have shown that certain ginsenosides (e.g., Rg1, Rb1, Re) can enhance mitochondrial biogenesis, improve mitochondrial membrane potential, promote ATP production, and reduce oxidative stress by upregulating antioxidant enzymes. These effects are thought to be mediated through pathways involving AMPK, SIRT1, and PGC-1α, all of which are critical regulators of mitochondrial health and energy metabolism.

For example, research published in Phytotherapy Research (2015) and Oxidative Medicine and Cellular Longevity (2019) has demonstrated that ginsenosides can protect mitochondria from damage in models of neurodegenerative disease and metabolic stress. Animal studies suggest that ginsenosides may enhance exercise endurance and cognitive function, possibly via mitochondrial mechanisms. However, direct evidence from human clinical trials is limited; most studies in humans use whole ginseng extracts rather than isolated ginsenosides and focus on endpoints like fatigue, mood, or glucose metabolism rather than explicit mitochondrial function.

In summary, while there is a moderate level of preclinical scientific evidence supporting the use of ginsenosides for mitochondrial health, human data are lacking and further research is needed to confirm these effects in clinical settings.

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Products containing Ginsenosides (unspecified)

We currently have no products on Vitabase that contain this ingredient.