Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glutathione is widely recognized for its role in supporting mitochondrial health, and this use is primarily justified by scientific evidence. Glutathione is a tripeptide composed of glutamine, cysteine, and glycine, and functions as a major endogenous antioxidant within cells. Its highest concentrations are found in the mitochondria, where it plays a crucial role in neutralizing reactive oxygen species (ROS) generated during cellular respiration. Excessive ROS can damage mitochondrial DNA, proteins, and lipids, leading to impaired energy production and even cell death.

Multiple studies have demonstrated that glutathione deficiency is linked to mitochondrial dysfunction and increased oxidative stress. Experimental research in cellular and animal models shows that depletion of glutathione leads to impaired mitochondrial function and increased susceptibility to oxidative damage, while supplementation or upregulation of glutathione can restore mitochondrial integrity and performance. For example, studies published in journals such as Biochimica et Biophysica Acta and Free Radical Biology and Medicine provide evidence that glutathione directly protects the mitochondrial membrane and supports ATP production.

However, it should be noted that while the mechanistic and preclinical evidence is strong, clinical trials in humans are more limited, especially regarding the direct effects of oral glutathione supplementation on mitochondrial function. Therefore, the evidence rating is moderate, reflecting robust laboratory support but less clinical validation.

More about Glutathione
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adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
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caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
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copper
creatine monohydrate
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epigallocatechin gallate (EGCG)
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fructose
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glycerophosphocholine (GPC)
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greens blend (proprietary)
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knotweed
krill oil
l-carnitine
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L-citrulline
L-glutathione
L-glycine
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lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
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magnesium
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malic acid
maltodextrin
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maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
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niacin (vitamin B3)
niacinamide (Vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic compounds
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
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quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
schisandra chinensis
selenium
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spinach
starch
stearic acid
strawberry
succinic acid
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thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
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ubiquinol
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vegetable and fruit blend (proprietary)
vitamin B
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Alpha polylactate
Apigenin
Alpha-Lipoic Acid
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Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
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Cocarboxylase
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Coenzyme A
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Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Flavin mononucleotide
Fish
Fatty acids
Fungus
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Flavones
Ginsenosides
Gamma-Glutamylcysteine
glucose
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Guanidinopropionic Acid (GPA )
Geranylgeraniol
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Honokiol
inosine
Idebenone
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methoxy-substituted benzoquinones
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NADH
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Other body systems supported by Glutathione

Blood
Brain
Gastrointestinal Tract
Heart
Hepatic System
Immune System
Intestinal System
Kidneys
Liver
Lungs
Mitochondria
Skin

Products containing Glutathione

We currently have no products on Vitabase that contain this ingredient.