Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Glutathione peroxidase (GPx) is an enzyme that plays a critical role in protecting cells, particularly mitochondria, from oxidative damage. Its primary function is to reduce hydrogen peroxide and organic hydroperoxides, converting them into water and corresponding alcohols using glutathione as a substrate. This detoxification mechanism is especially important in the mitochondrial body system, as mitochondria are a major source of reactive oxygen species (ROS) generated during cellular respiration. Excessive ROS can damage mitochondrial DNA, proteins, and lipids, impairing mitochondrial function and contributing to aging and disease processes.

Multiple scientific studies provide evidence for the importance of glutathione peroxidase in maintaining mitochondrial health. For example, animal models with GPx deficiency exhibit increased oxidative stress and mitochondrial dysfunction. In cell culture systems, overexpression of GPx has been shown to enhance resistance to oxidative stress and preserve mitochondrial integrity. Furthermore, research suggests that impaired GPx activity is associated with various mitochondrial-related disorders, including neurodegenerative diseases, cardiovascular disease, and metabolic syndromes (PMID: 15748623).

While the direct supplementation of GPx is not common, supporting its activity through adequate selenium intake (a cofactor for GPx) or maintaining glutathione levels is a recognized strategy. Overall, the scientific literature validates the essential role of glutathione peroxidase in mitochondrial defense against oxidative stress, justifying its use in supporting the mitochondrial body system.

More about Glutathione peroxidase
More about Mitochondria

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Other body systems supported by Glutathione peroxidase

Blood
Brain
Circulatory System
Gastrointestinal Tract
Heart
Hepatic System
Immune System
Intestinal System
Kidneys
Liver
Lungs
Mitochondria
Respiratory System

Products containing Glutathione peroxidase

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