Glycerophosphocholine (GPC), particularly in the form of alpha-GPC, is a compound that serves as a precursor to the neurotransmitter acetylcholine and is sometimes marketed for cognitive and neurological support. While GPC is primarily studied for its effects on brain health, memory, and cognitive function, there is emerging but limited scientific interest in its potential to support mitochondrial function. Some preclinical studies suggest that GPC may have indirect effects on mitochondrial health by improving membrane phospholipid composition and cellular signaling, which can influence mitochondrial biogenesis and resilience to stress. However, direct evidence in humans demonstrating substantial mitochondrial support is lacking. Most human studies on GPC focus on cognitive outcomes rather than explicit measures of mitochondrial function or health.

In summary, while there is a scientific rationale and some preliminary laboratory research indicating possible benefits of GPC for mitochondrial membranes or function, robust clinical evidence in this context is minimal. Thus, the use of GPC to support the mitochondrial body system is based on limited scientific validation, and the strength of evidence is currently low.