Grapes, particularly their seeds and skins, are rich in polyphenols such as resveratrol, quercetin, and proanthocyanidins, which have been studied for their potential to support mitochondrial health. Scientific research suggests that these compounds can exert antioxidant effects, reducing oxidative stress in mitochondria, which is a key factor in mitochondrial dysfunction. Resveratrol, in particular, has been shown in animal and cellular studies to activate sirtuins, a family of proteins involved in mitochondrial biogenesis and function. Some studies suggest that resveratrol can enhance mitochondrial function, improve energy metabolism, and protect against mitochondrial oxidative damage. However, the majority of this evidence comes from preclinical models (cell culture and animal studies) rather than large-scale human trials.

While there is a traditional use of grapes for general health, the specific link between grapes and mitochondrial support is driven primarily by recent scientific interest in polyphenols and their molecular mechanisms. Human studies are limited and often use purified compounds at higher doses than what is found in a typical grape serving. Therefore, while there is a scientific basis for the use of grape-derived compounds in supporting mitochondrial health, the strength of clinical evidence in humans is moderate, warranting a rating of 3 out of 5.