Synopsis

Source of validity: Scientific
Rating (out of 5): 3

GW501516, also known as Cardarine, is a synthetic agonist of the peroxisome proliferator-activated receptor delta (PPARδ). Its use in supporting the mitochondrial body system is grounded in scientific research, primarily preclinical studies in animals and in vitro models. GW501516 has been shown to enhance mitochondrial biogenesis and increase fatty acid oxidation in skeletal muscle cells by activating PPARδ. This activation leads to upregulation of genes involved in energy expenditure and mitochondrial function, which can improve endurance and overall cellular energy metabolism (Wang et al., Nature Medicine, 2004).

However, it is important to note that while these mechanistic effects on mitochondria are well-demonstrated in animal and cell studies, there is a lack of robust clinical evidence in humans regarding the safety and efficacy of GW501516 for mitochondrial support. Furthermore, GW501516 has raised serious safety concerns, including evidence of carcinogenicity in rodent models, which has led to the discontinuation of its clinical development for metabolic diseases. It is also classified as a prohibited substance by the World Anti-Doping Agency (WADA). In summary, the use of GW501516 to support mitochondrial function is supported by scientific research at the mechanistic and preclinical level, but not by human clinical trials, and its safety profile remains a significant concern.

More about GW501516
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by GW501516

Mitochondria
Muscles

Products containing GW501516

We currently have no products on Vitabase that contain this ingredient.