Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Honokiol is a bioactive compound extracted from the bark, seed cones, and leaves of trees belonging to the genus Magnolia. Its traditional use in East Asian herbal medicine focuses on anxiolytic, anti-inflammatory, and neuroprotective effects rather than direct mitochondrial support. However, in recent years, preclinical research has begun to explore honokiol’s impact on mitochondrial function. Laboratory and animal studies suggest that honokiol may enhance mitochondrial biogenesis, improve mitochondrial respiration, and protect mitochondria from oxidative stress. For example, studies in cultured cells indicate that honokiol can activate SIRT3, a mitochondrial deacetylase, and may increase the expression of PGC-1α, a regulator of mitochondrial biogenesis (Zhang et al., 2016). Animal research also suggests honokiol can mitigate mitochondrial dysfunction in models of neurodegenerative disease and ischemia-reperfusion injury. Despite these promising findings, there are no robust human clinical trials directly examining honokiol’s impact on mitochondrial health in vivo. Thus, while there is early scientific rationale and some preclinical evidence, the overall strength of evidence remains limited and does not yet support broad health claims. More rigorous human research is needed to establish honokiol’s efficacy and safety for mitochondrial support.

More about Honokiol
More about Mitochondria

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alpha-ketoglutarate (AKG)
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caffeine
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coenzyme Q10 (CoQ10)
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creatine monohydrate
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fructose
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hesperetin
knotweed
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l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
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malic acid
maltodextrin
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marine lipid
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medium chain triglycerides (MCT)
melatonin
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niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
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pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
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resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
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succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
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trans-pterostilbene
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Alpha polylactate
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adenosine triphosphate (ATP)
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Caffeic Acid
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Other body systems supported by Honokiol

Brain
GABA
Heart
Immune System
Lungs
Mitochondria
Nerves
Parasympathetic Nervous System

Products containing Honokiol

We currently have no products on Vitabase that contain this ingredient.