Evidence supporting the use of: Kaempferol
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Kaempferol is a natural flavonoid found in various fruits, vegetables, and medicinal plants. Recent scientific interest has focused on its potential to support mitochondrial function. Several in vitro and animal studies have demonstrated that kaempferol can enhance mitochondrial biogenesis and protect mitochondria from oxidative stress-induced damage. For example, research published in the journal Oxidative Medicine and Cellular Longevity (2017) found that kaempferol improved mitochondrial function and reduced oxidative stress in neuronal cells, potentially through activation of the Nrf2/ARE pathway and upregulation of antioxidant defenses. Other studies suggest that kaempferol may modulate mitochondrial dynamics, such as fusion and fission, and improve cellular energy metabolism by influencing key enzymes involved in the electron transport chain.

However, while the mechanistic data and preclinical findings are promising, there is currently a lack of robust human clinical trials directly linking kaempferol supplementation to improved mitochondrial function or related health outcomes. Most evidence remains preliminary and is primarily based on cell and animal models. As such, while scientific evidence exists for kaempferol’s positive impact on mitochondrial health at the experimental level, more research—particularly in humans—is needed before strong recommendations can be made. The overall scientific evidence supporting its use for mitochondrial support is therefore rated as moderate but not yet conclusive.

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Products containing Kaempferol

We currently have no products on Vitabase that contain this ingredient.