Evidence supporting the use of: Kaempferol
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Kaempferol is a natural flavonoid found in various fruits, vegetables, and medicinal plants. Recent scientific interest has focused on its potential to support mitochondrial function. Several in vitro and animal studies have demonstrated that kaempferol can enhance mitochondrial biogenesis and protect mitochondria from oxidative stress-induced damage. For example, research published in the journal Oxidative Medicine and Cellular Longevity (2017) found that kaempferol improved mitochondrial function and reduced oxidative stress in neuronal cells, potentially through activation of the Nrf2/ARE pathway and upregulation of antioxidant defenses. Other studies suggest that kaempferol may modulate mitochondrial dynamics, such as fusion and fission, and improve cellular energy metabolism by influencing key enzymes involved in the electron transport chain.
However, while the mechanistic data and preclinical findings are promising, there is currently a lack of robust human clinical trials directly linking kaempferol supplementation to improved mitochondrial function or related health outcomes. Most evidence remains preliminary and is primarily based on cell and animal models. As such, while scientific evidence exists for kaempferol’s positive impact on mitochondrial health at the experimental level, more research—particularly in humans—is needed before strong recommendations can be made. The overall scientific evidence supporting its use for mitochondrial support is therefore rated as moderate but not yet conclusive.
Other ingredients that support Mitochondria
1,3,7-Trimethylpurine-2,6-dione5-Aminoimidazole-4-Carboxamide Ribonucleotide
7-Keto-DHEA
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Algae
Alpha polylactate
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
apigenin
ashitaba
ashwagandha
Beef liver
berry
beta-hydroxybutyrate
black ginger
bovine liver
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
capsiate
capsinoids
cardarine
cardiolipin
catechins
centrophenoxine
chocolate
cistanche
citicoline
cocarboxylase
Coenzyme A
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine
creatine monohydrate
cyanidin
d-alpha tocopherol
D-Ribose
dihydrolipoic acid
electrolytes blend (proprietary)
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
fatty acids
fisetin
fish
fish oil
flavin mononucleotide
flavones
flavonols
fruit and vegetable blend (proprietary)
fucoxanthin
fulvic acid
fungus
gamma-glutamylcysteine
ganoderma
geranylgeraniol
Ginsenosides
glucose
Glutathione
glycerophosphocholine (GPC)
goji berry
gooseberry
grape
greens blend (proprietary)
guanidinopropionic acid (GPA )
Haematococcus pluvialis
herbal blend (proprietary)
hesperetin
Honokiol
Idebenone
inosine
Kaempferide
Kaempferol
ketone salts
knotweed
krill oil
l-carnitine
L-carnosine
L-citrulline
L-glutathione
L-glycine
L-taurine
Lentinula edodes mycelia
lingzhi
linoleic acid (LA)
lipids
liquid liver fractions
luteolin
magnesium
maitake mushroom
malic acid
manganese
maqui berry
Marine fat
Marine lipid
Matcha
medium chain triglycerides (MCT)
Melatonin
Methoxy-substituted benzoquinones
Methylxanthine
Moringa
Mushroom
Myricetin
NADH
Nannochloropsis
Naringenin
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nobiletin
oleanolic acid
Oleoyl-phosphatidylethanolamine
oxaloacetic acid
oxidase
pantethine
pantothenic acid (vitamin B5)
paraxanthine
phenolic compounds
phosphatidylcholine
Phosphatidylethanolamine
Phosphocreatine
Phytoplankton
Polydatin
polyphenols
Propionyl-L-Carnitine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
pyrroloquinoline quinone
pyruvate
quercetin
quinoa
quinone
resveratrol
Rhodiola
riboflavin (vitamin B2)
ribose
Ribose-l-cysteine
Rosarin
rosavins
rosemary
Salidroside
Schisandrins
selenium
Selenocysteine
Shilajit
spinach
Stilbenoid
strawberry
succinic acid
Sulforaphane
sulforaphane glucosinolate
Taxifolin
Tetradecylthioacetic acid
Thiamin (vitamin B1)
thyroid substance
tocotrienols
trace minerals
Trans-geranylgeraniol
Trans-pterostilbene
Triacetyluridine
tributyrin
Turkey tail mushroom
ubiquinol
Uridine
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
Watermelon
Withanolides
β-nicotinamide mononucleotide (NMN)
Other body systems supported by Kaempferol
ArteriesBlood
Brain
Circulatory System
Gastrointestinal Tract
Heart
Immune System
Intestinal System
Liver
Lungs
Mitochondria
Respiratory System
Skeletal System (Bones)
Skin
Stomach