Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ketone salts are supplements that provide exogenous ketones, typically beta-hydroxybutyrate (BHB), bound to minerals like sodium, potassium, or calcium. The rationale for their use in supporting mitochondrial function is based on the ability of ketones to serve as an alternative energy substrate for mitochondria, especially when glucose availability is low (e.g., during fasting or ketogenic diets). Ketones can be efficiently metabolized by mitochondria to generate ATP, which is the primary energy currency in cells.

Some preclinical and limited human studies suggest that ketone bodies may enhance mitochondrial efficiency, reduce the production of reactive oxygen species, and potentially improve cellular resilience under stress conditions. However, the majority of this evidence comes from animal studies, in vitro experiments, or from research using endogenous ketosis (i.e., through ketogenic diets), rather than exogenous ketone salt supplementation specifically.

There is a paucity of high-quality, long-term clinical trials directly demonstrating that ketone salts have a significant, sustained effect on mitochondrial function or health in humans. Most available studies are small, short-term, and often focused on athletic performance or cognitive effects rather than direct mitochondrial outcomes. Therefore, while there is a plausible scientific mechanism and some preliminary evidence, the overall strength of the evidence is limited at present.

More about Ketone Salts
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
L-carnosine
L-citrulline
L-glutathione
L-glycine
L-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (Vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic compounds
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
schisandra chinensis
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
Algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
Adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Flavin mononucleotide
Fish
Fatty acids
Fungus
Fucoxanthin
Flavones
Ginsenosides
Gamma-Glutamylcysteine
glucose
Glutathione
Guanidinopropionic Acid (GPA )
Geranylgeraniol
Haematococcus pluvialis
Honokiol
inosine
Idebenone
Kaempferol
Kaempferide
Ketone Salts
Lipids
methoxy-substituted benzoquinones
Myricetin
Methylxanthine
Marine fat
Mushroom
NADH
Naringenin
Nobiletin
Nannochloropsis
Oxaloacetic acid
Oleoyl-phosphatidylethanolamine
oxidase
Phosphocreatine
Pyrroloquinoline Quinone
Phosphatidylethanolamine
Paraxanthine
Phytoplankton
Polydatin
Propionyl-L-Carnitine
Pyruvate
Quinone
Rosavins
Ribose-l-cysteine
Rosarin
Ribose
Selenocysteine
Salidroside
Schisandrins
Shilajit
Stilbenoid
Sulforaphane
Tetradecylthioacetic acid
Taxifolin
Triacetyluridine
Uridine
Withanolides

Other body systems supported by Ketone Salts

Brain
Mitochondria

Products containing Ketone Salts

We currently have no products on Vitabase that contain this ingredient.