Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ketone salts are supplements that provide exogenous ketones, typically beta-hydroxybutyrate (BHB), bound to minerals like sodium, potassium, or calcium. The rationale for their use in supporting mitochondrial function is based on the ability of ketones to serve as an alternative energy substrate for mitochondria, especially when glucose availability is low (e.g., during fasting or ketogenic diets). Ketones can be efficiently metabolized by mitochondria to generate ATP, which is the primary energy currency in cells.

Some preclinical and limited human studies suggest that ketone bodies may enhance mitochondrial efficiency, reduce the production of reactive oxygen species, and potentially improve cellular resilience under stress conditions. However, the majority of this evidence comes from animal studies, in vitro experiments, or from research using endogenous ketosis (i.e., through ketogenic diets), rather than exogenous ketone salt supplementation specifically.

There is a paucity of high-quality, long-term clinical trials directly demonstrating that ketone salts have a significant, sustained effect on mitochondrial function or health in humans. Most available studies are small, short-term, and often focused on athletic performance or cognitive effects rather than direct mitochondrial outcomes. Therefore, while there is a plausible scientific mechanism and some preliminary evidence, the overall strength of the evidence is limited at present.

More about ketone salts
More about Mitochondria

Other ingredients that support Mitochondria

1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
7-Keto-DHEA
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Algae
Alpha polylactate
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
apigenin
ashitaba
ashwagandha
Beef liver
berry
beta-hydroxybutyrate
black ginger
bovine liver
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
capsiate
capsinoids
cardarine
cardiolipin
catechins
centrophenoxine
chocolate
cistanche
citicoline
cocarboxylase
Coenzyme A
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine
creatine monohydrate
cyanidin
d-alpha tocopherol
D-Ribose
dihydrolipoic acid
electrolytes blend (proprietary)
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
fatty acids
fisetin
fish
fish oil
flavin mononucleotide
flavones
flavonols
fruit and vegetable blend (proprietary)
fucoxanthin
fulvic acid
fungus
gamma-glutamylcysteine
ganoderma
geranylgeraniol
Ginsenosides
glucose
Glutathione
glycerophosphocholine (GPC)
goji berry
gooseberry
grape
greens blend (proprietary)
guanidinopropionic acid (GPA )
Haematococcus pluvialis
herbal blend (proprietary)
hesperetin
Honokiol
Idebenone
inosine
Kaempferide
Kaempferol
ketone salts
knotweed
krill oil
l-carnitine
L-carnosine
L-citrulline
L-glutathione
L-glycine
L-taurine
Lentinula edodes mycelia
lingzhi
linoleic acid (LA)
lipids
liquid liver fractions
luteolin
magnesium
maitake mushroom
malic acid
manganese
maqui berry
Marine fat
Marine lipid
Matcha
medium chain triglycerides (MCT)
Melatonin
Methoxy-substituted benzoquinones
Methylxanthine
Moringa
Mushroom
Myricetin
NADH
Nannochloropsis
Naringenin
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nobiletin
oleanolic acid
Oleoyl-phosphatidylethanolamine
oxaloacetic acid
oxidase
pantethine
pantothenic acid (vitamin B5)
paraxanthine
phenolic compounds
phosphatidylcholine
Phosphatidylethanolamine
Phosphocreatine
Phytoplankton
Polydatin
polyphenols
Propionyl-L-Carnitine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
pyrroloquinoline quinone
pyruvate
quercetin
quinoa
quinone
resveratrol
Rhodiola
riboflavin (vitamin B2)
ribose
Ribose-l-cysteine
Rosarin
rosavins
rosemary
Salidroside
Schisandrins
selenium
Selenocysteine
Shilajit
spinach
Stilbenoid
strawberry
succinic acid
Sulforaphane
sulforaphane glucosinolate
Taxifolin
Tetradecylthioacetic acid
Thiamin (vitamin B1)
thyroid substance
tocotrienols
trace minerals
Trans-geranylgeraniol
Trans-pterostilbene
Triacetyluridine
tributyrin
Turkey tail mushroom
ubiquinol
Uridine
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
Watermelon
Withanolides
β-nicotinamide mononucleotide (NMN)

Other body systems supported by ketone salts

Brain
Mitochondria

Products containing ketone salts

We currently have no products on Vitabase that contain this ingredient.