Lentinula edodes mycelia, commonly known as shiitake mushroom mycelia, have been studied primarily for their immunomodulatory, antioxidant, and anti-inflammatory properties. There is a growing body of research indicating that bioactive compounds found in shiitake mycelia—such as polysaccharides (notably beta-glucans), eritadenine, and various phenolic compounds—may have indirect effects on mitochondrial health. These effects are largely attributed to their capacity to reduce oxidative stress and modulate cellular signaling pathways that influence mitochondrial function.

Scientific studies in vitro and in animal models have shown that polysaccharide extracts from shiitake mushrooms can upregulate antioxidant enzymes (such as superoxide dismutase and catalase), thereby potentially protecting mitochondria from oxidative damage. Some research also suggests that these compounds may promote mitochondrial biogenesis and improve mitochondrial membrane potential. However, direct clinical evidence in humans linking Lentinula edodes mycelia supplementation to enhanced mitochondrial function is currently limited.

In summary, there is some preliminary scientific evidence—primarily from preclinical studies—for the use of Lentinula edodes mycelia in supporting mitochondrial health, mainly through antioxidant mechanisms. However, more rigorous human studies are needed to confirm these effects and establish clear efficacy.