Lingzhi (Ganoderma lucidum), also known as Reishi, has a long history in traditional Chinese medicine, but in recent years, some scientific studies have explored its potential effects on mitochondrial function. Laboratory and animal studies suggest that lingzhi contains bioactive compounds, such as polysaccharides and triterpenoids, which may influence mitochondrial health. Specifically, research has shown that these compounds can exhibit antioxidant effects, reduce oxidative stress, and help maintain mitochondrial membrane potential in cell models. For example, some studies have demonstrated that extract of Ganoderma lucidum can protect neuronal and cardiac cells from oxidative damage by enhancing mitochondrial antioxidant enzymes and reducing mitochondrial dysfunction.

However, most of this evidence comes from in vitro (test tube) or animal studies, and there is very limited direct clinical evidence in humans linking lingzhi supplementation to improved mitochondrial function or health. The mechanisms proposed are plausible, as oxidative stress is a well-known factor in mitochondrial dysfunction, and antioxidants can theoretically offer some protection. Still, large, well-controlled human studies are lacking. Therefore, while there is emerging scientific interest and some early supportive data, the strength of evidence for lingzhi’s impact on the mitochondrial system is currently limited and preliminary.