Evidence supporting the use of: Lipids
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Lipids play a crucial role in supporting mitochondrial function, and their use for this purpose is strongly supported by scientific evidence. Mitochondria are the primary organelles for energy production in cells, generating ATP through oxidative phosphorylation. The mitochondrial membranes, particularly the inner membrane, are composed largely of phospholipids and specific lipid types such as cardiolipin. These lipids are essential for maintaining mitochondrial structure, fluidity, and the proper functioning of protein complexes involved in the electron transport chain.

Research shows that deficiencies or imbalances in mitochondrial lipids, especially cardiolipin, can impair mitochondrial bioenergetics and are linked to various diseases, including Barth syndrome and neurodegenerative disorders. Supplementation with certain lipids, such as phospholipids (e.g., phosphatidylcholine) and omega-3 fatty acids, has been shown in some studies to improve mitochondrial membrane composition and function. For example, omega-3 fatty acids can enhance mitochondrial biogenesis and efficiency, while phospholipids can help repair damaged mitochondrial membranes.

Therefore, the use of lipids to support mitochondrial health is scientifically grounded, with a strong mechanistic basis and growing evidence from both basic research and clinical studies. However, the evidence is not yet conclusive for all types of lipids or all health conditions, so the rating is 4 out of 5.

More about lipids
More about Mitochondria

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alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
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ampelopsin
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apigenin
ashitaba
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beta-hydroxybutyrate
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bovine liver
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caffeic Acid
caffeine
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capsiate
capsinoids
cardarine
cardiolipin
catechins
centrophenoxine
chocolate
cistanche
citicoline
cocarboxylase
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coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine
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cyanidin
d-alpha tocopherol
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dihydrolipoic acid
electrolytes blend (proprietary)
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
fatty acids
fisetin
fish
fish oil
flavin mononucleotide
flavones
flavonols
fruit and vegetable blend (proprietary)
fucoxanthin
fulvic acid
fungus
gamma-glutamylcysteine
ganoderma
geranylgeraniol
Ginsenosides
glucose
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glycerophosphocholine (GPC)
goji berry
gooseberry
grape
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guanidinopropionic acid (GPA )
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herbal blend (proprietary)
hesperetin
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ketone salts
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l-carnitine
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pantethine
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ribose
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thyroid substance
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Products containing lipids

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