Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnesium Alpha-Ketoglutarate (Mg-AKG) is a compound combining magnesium, an essential mineral, and alpha-ketoglutarate (AKG), a key intermediate in the Krebs (citric acid) cycle within mitochondria. The rationale for its use in supporting mitochondrial function is grounded in the biological roles of both components. Magnesium is well-established as a cofactor in hundreds of enzymatic reactions, many of which occur in mitochondrial energy metabolism. AKG, on the other hand, is directly involved in the Krebs cycle, which is central to cellular ATP production. Some animal and in vitro studies have shown that AKG supplementation can enhance mitochondrial function, reduce oxidative stress, and promote cellular energy production. However, direct clinical evidence in humans using Mg-AKG specifically for mitochondrial support is limited. Most human studies focus on AKG or magnesium individually, and while both show benefit in supporting general cellular metabolism and reducing fatigue, robust clinical trials specifically investigating Mg-AKG for mitochondrial health are lacking. In summary, the use of Magnesium Alpha-Ketoglutarate to support mitochondrial function is scientifically plausible based on its biochemical roles, and there is some preclinical evidence. However, the strength of direct clinical evidence in humans is modest, justifying a low-to-moderate evidence rating.

More about Magnesium Alpha-Ketoglutarate
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
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ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
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Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by Magnesium Alpha-Ketoglutarate

Mitochondria

Products containing Magnesium Alpha-Ketoglutarate

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