Marine lipids, particularly omega-3 polyunsaturated fatty acids such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are supported by scientific evidence for their role in supporting mitochondrial function, though most of the evidence is preclinical or mechanistic, with some emerging human data. Mitochondria are the energy-producing organelles of cells, and their function is crucial for energy metabolism, cellular health, and the prevention of oxidative stress.

Several in vitro and animal studies have demonstrated that omega-3 fatty acids from marine lipids can improve mitochondrial biogenesis (the process of making new mitochondria), enhance mitochondrial respiration, and reduce the production of reactive oxygen species (ROS). These effects are attributed to the incorporation of EPA and DHA into mitochondrial membranes, which enhances membrane fluidity and function, and modulates the activity of mitochondrial enzymes. Some research also suggests that omega-3s may protect mitochondria from damage associated with aging and metabolic diseases.

While direct studies in humans are less abundant, some clinical trials have shown that omega-3 supplementation can improve markers of mitochondrial function in conditions such as metabolic syndrome and neurodegenerative diseases. Nevertheless, more robust human data are needed to fully confirm the efficacy of marine lipids for supporting mitochondrial health. Therefore, the scientific evidence is promising but not yet definitive, meriting a moderate evidence rating.