Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Melatonin is primarily known as a regulator of circadian rhythms and sleep, but emerging scientific research suggests that it also plays a significant role in supporting mitochondrial function. Melatonin is a potent antioxidant, capable of directly scavenging free radicals and upregulating antioxidant enzymes within the mitochondria. Studies in cell cultures, animal models, and some early human research indicate that melatonin can protect mitochondrial DNA, proteins, and lipids from oxidative damage. It also appears to enhance mitochondrial efficiency by improving the electron transport chain function and reducing the generation of reactive oxygen species (ROS). Furthermore, melatonin has been shown to regulate mitochondrial biogenesis and prevent mitochondrial permeability transition pore opening, thereby safeguarding cells from apoptosis under stress conditions.

While most of the evidence comes from preclinical studies, a growing body of literature supports the potential application of melatonin in conditions characterized by mitochondrial dysfunction, such as neurodegenerative diseases, metabolic disorders, and aging. However, large-scale, controlled human trials specifically examining melatonin’s benefit to mitochondrial health remain limited. Thus, while there is a scientific basis for its use in supporting mitochondrial function, the evidence is not yet robust enough to warrant a higher rating.

In summary, melatonin’s role in mitochondrial support is grounded in scientific research, mainly at the experimental and preclinical level, and warrants further clinical investigation.

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Products containing melatonin

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Pure Encapsulations Melatonin 0.5 mg
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Pure Encapsulations Melatonin 20 mg
Pure Encapsulations Melatonin 20 mg
Pure Encapsulations Melatonin 3 mg
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Metagenics MetaSleep®
Integrative Therapeutics ProThrivers Wellness Sleep