Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Methylxanthines, including caffeine, theobromine, and theophylline, are a class of compounds found in coffee, tea, and chocolate. There is scientific evidence that methylxanthines affect mitochondrial function, primarily through their role as adenosine receptor antagonists and phosphodiesterase inhibitors. These mechanisms can increase intracellular cyclic AMP (cAMP) levels, which in turn may influence mitochondrial biogenesis and energy metabolism. Studies have shown that caffeine can enhance mitochondrial respiration and protect against mitochondrial dysfunction in both cellular and animal models. For example, research published in Cell Reports (2017) demonstrated that caffeine promotes mitochondrial biogenesis and function in skeletal muscle through the activation of AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α) pathways. However, most evidence comes from preclinical studies, and robust clinical trials in humans are limited. While the cellular data is promising, the translation to meaningful mitochondrial support in the context of human health and disease requires further investigation. Thus, the use of methylxanthines to support mitochondrial function is supported by a moderate level of scientific evidence, but more human studies are needed for definitive conclusions.

More about Methylxanthine
More about Mitochondria

Other ingredients that support Mitochondria

1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
7-Keto-DHEA
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Algae
Alpha polylactate
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
apigenin
ashitaba
ashwagandha
Beef liver
berry
beta-hydroxybutyrate
black ginger
bovine liver
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
capsiate
capsinoids
cardarine
cardiolipin
catechins
centrophenoxine
chocolate
cistanche
citicoline
cocarboxylase
Coenzyme A
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine
creatine monohydrate
cyanidin
d-alpha tocopherol
D-Ribose
dihydrolipoic acid
electrolytes blend (proprietary)
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
fatty acids
fisetin
fish
fish oil
flavin mononucleotide
flavones
flavonols
fruit and vegetable blend (proprietary)
fucoxanthin
fulvic acid
fungus
gamma-glutamylcysteine
ganoderma
geranylgeraniol
Ginsenosides
glucose
Glutathione
glycerophosphocholine (GPC)
goji berry
gooseberry
grape
greens blend (proprietary)
guanidinopropionic acid (GPA )
Haematococcus pluvialis
herbal blend (proprietary)
hesperetin
Honokiol
Idebenone
inosine
Kaempferide
Kaempferol
ketone salts
knotweed
krill oil
l-carnitine
L-carnosine
L-citrulline
L-glutathione
L-glycine
L-taurine
Lentinula edodes mycelia
lingzhi
linoleic acid (LA)
lipids
liquid liver fractions
luteolin
magnesium
maitake mushroom
malic acid
manganese
maqui berry
Marine fat
Marine lipid
Matcha
medium chain triglycerides (MCT)
Melatonin
Methoxy-substituted benzoquinones
Methylxanthine
Moringa
Mushroom
Myricetin
NADH
Nannochloropsis
Naringenin
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nobiletin
oleanolic acid
Oleoyl-phosphatidylethanolamine
oxaloacetic acid
oxidase
pantethine
pantothenic acid (vitamin B5)
paraxanthine
phenolic compounds
phosphatidylcholine
Phosphatidylethanolamine
Phosphocreatine
Phytoplankton
Polydatin
polyphenols
Propionyl-L-Carnitine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
pyrroloquinoline quinone
pyruvate
quercetin
quinoa
quinone
resveratrol
Rhodiola
riboflavin (vitamin B2)
ribose
Ribose-l-cysteine
Rosarin
rosavins
rosemary
Salidroside
Schisandrins
selenium
Selenocysteine
Shilajit
spinach
Stilbenoid
strawberry
succinic acid
Sulforaphane
sulforaphane glucosinolate
Taxifolin
Tetradecylthioacetic acid
Thiamin (vitamin B1)
thyroid substance
tocotrienols
trace minerals
Trans-geranylgeraniol
Trans-pterostilbene
Triacetyluridine
tributyrin
Turkey tail mushroom
ubiquinol
Uridine
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
Watermelon
Withanolides
β-nicotinamide mononucleotide (NMN)

Other body systems supported by Methylxanthine

Arteries
Blood
Brain
Bronchials
Circulatory System
Epinephrine
Heart
Lungs
Mitochondria
Muscles
Nerves
Respiratory System
Sympathetic Nervous System

Products containing Methylxanthine

We currently have no products on Vitabase that contain this ingredient.