Synopsis

Source of validity: Scientific
Rating (out of 5): 2

NADH (nicotinamide adenine dinucleotide + hydrogen) is a coenzyme found in all living cells and plays a critical role in mitochondrial energy production. In the mitochondria, NADH acts as an electron donor in the electron transport chain, helping generate ATP—the cell’s main energy currency. This biochemical function is well established in scientific literature and is universally recognized in cellular biology.

Supplemental NADH has been studied for its potential to enhance mitochondrial function and energy metabolism, particularly in conditions characterized by fatigue such as chronic fatigue syndrome (CFS) and fibromyalgia. Some small clinical trials and pilot studies suggest that NADH supplementation may improve energy levels and cognitive function in such populations, but results are mixed and not consistently reproducible. There’s also limited evidence for its use in neurodegenerative diseases like Parkinson’s disease, with some early studies noting modest benefits, but again, data are not robust.

Overall, while the role of NADH within mitochondria is scientifically validated, the evidence for oral NADH supplementation directly supporting mitochondrial health or function in otherwise healthy individuals is limited and not conclusive. Most clinical studies are small, short-term, and often lack rigorous controls. Therefore, while NADH’s use is grounded in its biological role, strong clinical validation for supplementation is lacking, justifying a moderate evidence score.

More about NADH
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by NADH

Brain
Heart
Immune System
Mitochondria
Muscles
Nerves
Specific Neurotransmitters

Products containing NADH

We currently have no products on Vitabase that contain this ingredient.