Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Naringenin is a flavonoid found predominantly in citrus fruits. Its use to support mitochondrial health is primarily based on preclinical scientific studies rather than traditional medicine. Several in vitro and animal studies suggest that naringenin exhibits antioxidant, anti-inflammatory, and mitochondrial-protective properties. Research indicates that naringenin can enhance mitochondrial biogenesis, improve mitochondrial function, and reduce oxidative stress, which collectively may protect against mitochondrial dysfunction involved in metabolic and neurodegenerative diseases. For example, studies in rodents have demonstrated that naringenin supplementation can improve markers of mitochondrial function in liver and brain tissues, as well as reduce mitochondrial-related oxidative damage. The proposed mechanisms include activation of the PGC-1α pathway (a master regulator of mitochondrial biogenesis) and modulation of cellular antioxidant defenses.

However, direct clinical evidence in humans is lacking. Most evidence comes from cell culture and animal models, and there are no large-scale human trials that specifically test naringenin for mitochondrial support. As a result, while the ingredient is justified by emerging scientific research, the current level of evidence is modest and preliminary, warranting a score of 2 out of 5. More robust human studies are needed to confirm its efficacy and safety for supporting mitochondrial health.

More about Naringenin
More about Mitochondria

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caffeic Acid
caffeine
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capsiate
capsinoids
cardarine
cardiolipin
catechins
centrophenoxine
chocolate
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fucoxanthin
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glycerophosphocholine (GPC)
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pantethine
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Other body systems supported by Naringenin

Arteries
Blood
Brain
Circulatory System
Gastrointestinal Tract
Heart
Hepatic System
Immune System
Intestinal System
Liver
Mitochondria
Respiratory System
Skin

Products containing Naringenin

We currently have no products on Vitabase that contain this ingredient.