Evidence supporting the use of: Naringenin
For the body system: Mitochondria

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Naringenin is a flavonoid found predominantly in citrus fruits. Its use to support mitochondrial health is primarily based on preclinical scientific studies rather than traditional medicine. Several in vitro and animal studies suggest that naringenin exhibits antioxidant, anti-inflammatory, and mitochondrial-protective properties. Research indicates that naringenin can enhance mitochondrial biogenesis, improve mitochondrial function, and reduce oxidative stress, which collectively may protect against mitochondrial dysfunction involved in metabolic and neurodegenerative diseases. For example, studies in rodents have demonstrated that naringenin supplementation can improve markers of mitochondrial function in liver and brain tissues, as well as reduce mitochondrial-related oxidative damage. The proposed mechanisms include activation of the PGC-1α pathway (a master regulator of mitochondrial biogenesis) and modulation of cellular antioxidant defenses.

However, direct clinical evidence in humans is lacking. Most evidence comes from cell culture and animal models, and there are no large-scale human trials that specifically test naringenin for mitochondrial support. As a result, while the ingredient is justified by emerging scientific research, the current level of evidence is modest and preliminary, warranting a score of 2 out of 5. More robust human studies are needed to confirm its efficacy and safety for supporting mitochondrial health.

More about Naringenin
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Products containing Naringenin

We currently have no products on Vitabase that contain this ingredient.