Relationship: Mitochondria and niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Niacin (vitamin B3) plays a scientifically validated role in supporting mitochondrial function. Niacin is a precursor for the coenzymes nicotinamide adenine dinucleotide (NAD⁺) and nicotinamide adenine dinucleotide phosphate (NADP⁺), which are essential for mitochondrial energy metabolism. NAD⁺ is a key electron carrier in the mitochondrial electron transport chain, facilitating oxidative phosphorylation and ATP production. Deficiency of niacin impairs mitochondrial energy generation, resulting in cellular dysfunction and clinical conditions such as pellagra.

Recent research has focused on the role of NAD⁺ in mitochondrial health and aging. Studies in cell and animal models have shown that supplementation with niacin or related compounds can boost NAD⁺ levels, improve mitochondrial function, and enhance resistance to metabolic stress. In humans, clinical trials have demonstrated that niacin supplementation increases NAD⁺ availability, though direct evidence for long-term improvements in mitochondrial function or specific health outcomes remains limited.

Overall, the use of niacin to support mitochondrial function is grounded in established biochemistry and supported by emerging research, but high-quality clinical evidence in humans is moderate rather than definitive. Therefore, niacin is scientifically justified for mitochondrial support, with a moderate evidence rating.

More about niacin (vitamin B3)
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Other ingredients that support Mitochondria

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adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
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caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
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epigallocatechin gallate (EGCG)
fisetin
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flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
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hesperetin
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krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
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magnesium
maitake mushroom
malic acid
maltodextrin
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maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
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niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
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resveratrol
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riboflavin (vitamin B2)
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spinach
starch
stearic acid
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succinic acid
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thiamin (vitamin B1)
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Other body systems supported by niacin (vitamin B3)

Arteries
Blood
Brain
Circulatory System
Digestive System
Glandular System
Heart
Hepatic System
Immune System
Liver
Mitochondria
Mucus Membranes
Nerves
Skin

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Evidence supporting the use of: Niacin (vitamin B3)
For the body system: Mitochondria

Table of Contents

Synopsis

Other ingredients that support Mitochondria

Other body systems supported by niacin (vitamin B3)

Products containing niacin (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)For the body system: Mitochondria

Table of Contents

Synopsis

Other ingredients that support Mitochondria

Other body systems supported by niacin (vitamin B3)

Products containing niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the body system: Mitochondria