Oleoyl-phosphatidylethanolamine (OPE), a derivative of phosphatidylethanolamine (PE) containing an oleic acid chain, is a component of cell membranes, including those of mitochondria. Scientific interest in OPE and related phospholipids has grown due to their roles in mitochondrial structure and function. PE is one of the most abundant phospholipids in the inner mitochondrial membrane and is essential for the optimal function of several mitochondrial enzymes, including those involved in oxidative phosphorylation. Some studies have shown that alterations in mitochondrial PE levels can lead to impaired mitochondrial bioenergetics, increased oxidative stress, and defects in mitochondrial dynamics.

In terms of supplementation, research on direct administration of OPE to support human mitochondrial function is limited. Most scientific evidence comes from biochemical and cell biology studies rather than clinical trials. Animal and in vitro studies suggest that restoring or maintaining adequate PE levels supports mitochondrial integrity and function, potentially benefiting cellular energy metabolism and reducing mitochondrial-associated dysfunction. However, specific studies on OPE supplementation in humans for mitochondrial health are sparse, and evidence for clinical efficacy is not robust at this time.

In summary, the use of OPE to support mitochondrial health has a scientific basis rooted in the fundamental role of PE in mitochondrial membranes and function, but direct evidence for clinical benefits of OPE supplementation remains limited, justifying a moderate rating of 3 out of 5.