Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Oxaloacetate is a key metabolic intermediate in the citric acid (Krebs) cycle, which is central to mitochondrial energy production. Scientific interest in oxaloacetate supplementation has grown due to its role in cellular metabolism and energy generation. Preclinical research, particularly in animal models, indicates that oxaloacetate supplementation can enhance mitochondrial function, increase the NAD+/NADH ratio, and potentially improve cellular energy status. Some studies have shown benefits in models of neurodegeneration and aging, likely due to improved mitochondrial resilience and bioenergetics. Human research is limited, but a few small pilot studies suggest potential cognitive and energy benefits, though these findings are preliminary and not yet conclusive. Mechanistically, oxaloacetate supports mitochondrial health by facilitating the efficient flow of the Krebs cycle, thereby optimizing ATP production. Additionally, its role in gluconeogenesis and as an antioxidant may further support cellular health under stress. However, there is not yet robust clinical evidence in humans to fully validate its effectiveness for mitochondrial support as a dietary supplement. Most claims are based on mechanistic plausibility and early-stage studies. Thus, while there is a scientific foundation for its use and moderate evidence from animal and pilot human studies, larger and more rigorous clinical trials are needed to establish its efficacy in supporting mitochondrial function in humans.

More about Oxaloacetate
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
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ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by Oxaloacetate

Brain
Mitochondria

Products containing Oxaloacetate

We currently have no products on Vitabase that contain this ingredient.