Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oxaloacetic acid (also known as oxaloacetate) is a key intermediate in the citric acid (Krebs) cycle, which is central to mitochondrial energy production. Its role in cellular metabolism has prompted scientific investigation into its potential as a dietary supplement to support mitochondrial function. Preclinical studies, primarily in animal models and cell cultures, suggest that oxaloacetate supplementation may help modulate mitochondrial metabolism, reduce oxidative stress, and support cellular energy production. Some pilot human studies have explored its effects on fatigue and age-related metabolic decline, but robust clinical data are lacking.

While there is a plausible biochemical rationale and some early-stage research indicating that oxaloacetate may support mitochondrial health, the evidence remains limited. Most available data come from mechanistic studies or small, uncontrolled human trials. There is not yet strong clinical evidence to support its widespread use for mitochondrial support in humans. Therefore, the scientific validation is preliminary, and the strength of evidence is currently rated as low (2 out of 5). Further well-controlled, large-scale clinical trials are needed to confirm any definitive benefits of oxaloacetate supplementation for mitochondrial function in humans.

More about oxaloacetic acid
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
L-carnosine
L-citrulline
L-glutathione
L-glycine
L-taurine
Lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
Marine lipid
Matcha
medium chain triglycerides (MCT)
Melatonin
Moringa
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic compounds
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
Rhodiola
riboflavin (vitamin B2)
rosemary
sardines
Schisandra chinensis
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
Thiamin (vitamin B1)
tocotrienols
Trans-geranylgeraniol
Trans-pterostilbene
tributyrin
Turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
Water
Watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
Algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
apigenin
alpha-lipoic acid
ampelopsin
Adenosine triphosphate (ATP)
animal protein
beta-hydroxybutyrate
Beef liver
berry
caffeic Acid
centrophenoxine
Camellia sinensis
cardarine
cocarboxylase
capsinoids
Coenzyme A
cardiolipin
cyanidin
capsiate
chocolate
creatine
C-phycocyanin
dihydrolipoic acid
D-Ribose
eriocitrin
ergothioneine
flavin mononucleotide
fish
fatty acids
fungus
fucoxanthin
flavones
Ginsenosides
gamma-glutamylcysteine
glucose
Glutathione
guanidinopropionic acid (GPA )
geranylgeraniol
Haematococcus pluvialis
Honokiol
inosine
Idebenone
Kaempferol
Kaempferide
ketone salts
lipids
Methoxy-substituted benzoquinones
Myricetin
Methylxanthine
Marine fat
Mushroom
NADH
Naringenin
Nobiletin
Nannochloropsis
oxaloacetic acid
Oleoyl-phosphatidylethanolamine
oxidase
Phosphocreatine
pyrroloquinoline quinone
Phosphatidylethanolamine
paraxanthine
Phytoplankton
Polydatin
Propionyl-L-Carnitine
pyruvate
quinone
rosavins
Ribose-l-cysteine
Rosarin
ribose
Selenocysteine
Salidroside
Schisandrins
Shilajit
Stilbenoid
Sulforaphane
Tetradecylthioacetic acid
Taxifolin
Triacetyluridine
Uridine
Withanolides

Other body systems supported by oxaloacetic acid

Brain
Mitochondria

Products containing oxaloacetic acid

We currently have no products on Vitabase that contain this ingredient.