Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Paraxanthine is a primary metabolite of caffeine, resulting from the demethylation of caffeine in the liver. Its direct use as a supplement is relatively new, but recent research has begun to explore its pharmacological effects. The rationale for using paraxanthine to support mitochondrial function stems from its structural similarity to caffeine and its ability to act as an adenosine receptor antagonist. This action can increase alertness and stimulate cellular metabolism, potentially influencing mitochondrial activity indirectly via increased energy demand and enhanced cellular signaling.

Several in vitro and animal studies indicate that paraxanthine can enhance cyclic AMP (cAMP) levels, which may upregulate mitochondrial biogenesis and function through pathways involving PGC-1α, a key regulator of mitochondrial health. However, direct evidence in humans demonstrating paraxanthine’s specific benefits for mitochondrial function is limited. Most human data focus on its psychoactive and cardiovascular effects, not direct mitochondrial outcomes.

In summary, while there is a plausible scientific mechanism and some early supportive evidence, robust clinical trials confirming paraxanthine’s efficacy for mitochondrial support are lacking. Therefore, the scientific validation is limited, and the evidence level remains modest.

More about Paraxanthine
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Fish
Fatty acids
glucose
Ketone Salts

Other body systems supported by Paraxanthine

Brain
Dopamine
Mitochondria
Sympathetic Nervous System

Products containing Paraxanthine

We currently have no products on Vitabase that contain this ingredient.