Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Paraxanthine is a primary metabolite of caffeine, resulting from the demethylation of caffeine in the liver. Its direct use as a supplement is relatively new, but recent research has begun to explore its pharmacological effects. The rationale for using paraxanthine to support mitochondrial function stems from its structural similarity to caffeine and its ability to act as an adenosine receptor antagonist. This action can increase alertness and stimulate cellular metabolism, potentially influencing mitochondrial activity indirectly via increased energy demand and enhanced cellular signaling.

Several in vitro and animal studies indicate that paraxanthine can enhance cyclic AMP (cAMP) levels, which may upregulate mitochondrial biogenesis and function through pathways involving PGC-1α, a key regulator of mitochondrial health. However, direct evidence in humans demonstrating paraxanthine’s specific benefits for mitochondrial function is limited. Most human data focus on its psychoactive and cardiovascular effects, not direct mitochondrial outcomes.

In summary, while there is a plausible scientific mechanism and some early supportive evidence, robust clinical trials confirming paraxanthine’s efficacy for mitochondrial support are lacking. Therefore, the scientific validation is limited, and the evidence level remains modest.

More about paraxanthine
More about Mitochondria

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Other body systems supported by paraxanthine

Brain
Dopamine
Mitochondria
Sympathetic Nervous System

Products containing paraxanthine

We currently have no products on Vitabase that contain this ingredient.