Phosphatidylcholine (PC) is a major phospholipid component of cell membranes, including those of the mitochondria. Its primary traditional use has been for liver health, but there is emerging scientific interest in its role in mitochondrial function. PC serves as a source of choline, which is important for the synthesis of acetylcholine and the maintenance of membrane integrity. The mitochondria rely on phospholipids like PC to preserve membrane fluidity and enable proper function, such as ATP production and protection against oxidative stress.

Some preclinical studies suggest that supplementation with phosphatidylcholine may help restore mitochondrial membrane composition in conditions of mitochondrial dysfunction. For example, alterations in mitochondrial phospholipids have been observed in neurodegenerative diseases and aging, and replenishing PC has shown potential to improve mitochondrial function in cellular and animal models. However, direct clinical evidence in humans demonstrating a clear benefit of PC supplementation for mitochondrial health is limited. Most of the current support comes from mechanistic research and animal studies rather than robust human trials.

In summary, while there is a scientific rationale and some experimental evidence for the use of phosphatidylcholine to support mitochondrial health, strong clinical validation is lacking. The evidence is preliminary, justifying a mid-to-low evidence rating.