Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Phosphatidylethanolamine (PE) is a major phospholipid component of biological membranes, including those of the mitochondria. It plays a critical role in maintaining mitochondrial membrane integrity, shape, and function. Scientific research demonstrates that PE is essential for mitochondrial bioenergetics, as it supports membrane curvature and the assembly of mitochondrial protein complexes involved in oxidative phosphorylation. Mice and yeast models with genetically impaired PE biosynthesis exhibit mitochondrial dysfunction, altered energy metabolism, and increased oxidative stress, indicating that adequate PE is crucial for optimal mitochondrial activity.

Supplementation or increased biosynthesis of PE has been studied in the context of mitochondrial diseases and aging, with some preclinical models showing improved mitochondrial morphology and function. However, direct clinical trials in humans using oral PE supplementation specifically to enhance mitochondrial function are lacking. Most evidence comes from in vitro, animal, and mechanistic studies. PE is sometimes included in mitochondrial support supplements based on its biological role, but the translation from basic science research to clinical benefit in humans is not yet fully established.

In summary, there is scientific rationale and experimental evidence supporting the importance of phosphatidylethanolamine for mitochondrial health, but robust human clinical evidence for supplementation benefits remains limited. Therefore, the evidence rating is moderate.

More about Phosphatidylethanolamine
More about Mitochondria

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alpha-ketoglutarate (AKG)
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coenzyme Q10 (CoQ10)
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creatine monohydrate
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flavonols
fructose
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gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
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malic acid
maltodextrin
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manganese
maqui berry
marine lipid
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medium chain triglycerides (MCT)
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niacin (vitamin B3)
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pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
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resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
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trans-pterostilbene
tributyrin
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ubiquinol
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vegetable and fruit blend (proprietary)
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Alpha polylactate
Apigenin
Alpha-Lipoic Acid
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adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
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Cocarboxylase
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Other body systems supported by Phosphatidylethanolamine

Brain
Mitochondria
Nerves

Products containing Phosphatidylethanolamine

We currently have no products on Vitabase that contain this ingredient.