Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidylethanolamine (PE) is a major phospholipid found in biological membranes, including those of mitochondria. Scientific studies demonstrate that PE is critical for mitochondrial structure and function. In mitochondria, PE is involved in maintaining membrane curvature and integrity, supporting the activity of membrane proteins, and facilitating the assembly and stability of protein complexes involved in oxidative phosphorylation. Animal and cellular research shows that deficiencies in mitochondrial PE can impair mitochondrial respiration and morphology, leading to reduced energy production and increased susceptibility to stress. For example, research published in journals such as Cell Metabolism and Nature Communications has shown that genetic disruption of PE synthesis results in mitochondrial dysfunction and related cellular pathologies.

However, direct evidence from human clinical supplementation studies demonstrating that dietary or supplemental PE improves mitochondrial health or function is lacking. Most evidence is mechanistic or derived from in vitro or animal models. Thus, while there is scientific rationale and mechanistic support for the importance of PE in mitochondrial biology, the evidence supporting the use of supplemental PE specifically to support human mitochondrial health is limited and indirect. This places the evidence at a moderate-low level (2/5), indicating a promising but not yet clinically validated role for PE supplementation in supporting mitochondrial function.

More about Phosphotidylethanolamine
More about Mitochondria

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creatine monohydrate
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fructose
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gooseberry
grape
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hesperetin
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l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
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malic acid
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marine lipid
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medium chain triglycerides (MCT)
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niacin (vitamin B3)
niacinamide (vitamin B3)
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pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
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quercetin
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resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
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selenium
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spinach
starch
stearic acid
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succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
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trans-pterostilbene
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ubiquinol
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Alpha polylactate
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adenosine triphosphate (ATP)
Animal protein
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Caffeic Acid
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Other body systems supported by Phosphotidylethanolamine

Mitochondria
Nerves

Products containing Phosphotidylethanolamine

We currently have no products on Vitabase that contain this ingredient.