Evidence supporting the use of: Polyphenols (various)
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyphenols, a diverse group of naturally occurring compounds found in plant foods such as fruits, vegetables, tea, coffee, and wine, have garnered scientific interest for their potential to support mitochondrial function. Research indicates that polyphenols can exert beneficial effects on mitochondria through several mechanisms, including antioxidant activity, modulation of mitochondrial biogenesis, and improvement of mitochondrial efficiency. Key polyphenols like resveratrol, quercetin, and epigallocatechin gallate (EGCG) have been shown in vitro and in animal studies to stimulate the activation of SIRT1 and PGC-1α, which are critical regulators of mitochondrial biogenesis and function. Additionally, polyphenols can help protect mitochondrial DNA and proteins against oxidative damage by neutralizing reactive oxygen species (ROS). Some small human studies suggest that polyphenol-rich diets or supplements may enhance markers of mitochondrial health, such as increased mitochondrial enzyme activity or improved exercise performance, though findings are not entirely consistent and often limited by small sample sizes and short durations. Despite promising preclinical data, more robust clinical trials are needed to fully establish efficacy in humans. Nevertheless, there is a growing body of scientific evidence supporting the role of various polyphenols in supporting mitochondrial health, earning a moderate evidence rating.

More about polyphenols (various)
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Products containing polyphenols (various)

We currently have no products on Vitabase that contain this ingredient.