Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Synopsis of Evidence for Propionyl-L-Carnitine and Mitochondrial Support

Propionyl-L-carnitine (PLC) is a derivative of L-carnitine, a compound involved in mitochondrial fatty acid transport and energy production. The scientific rationale for using PLC to support mitochondrial function is based on its role in facilitating the transport of long-chain fatty acids into mitochondria, thereby aiding in beta-oxidation and ATP production. Several clinical and preclinical studies have explored PLC's potential to support mitochondrial health, particularly in the context of cardiovascular diseases and peripheral arterial disease (PAD).

A number of studies have demonstrated that PLC supplementation can improve symptoms related to impaired mitochondrial function, such as muscle fatigue and exercise intolerance, especially in patients with PAD. For example, a randomized controlled trial published in Circulation (1998) found that PLC improved walking distance in patients with intermittent claudication, a condition often linked to compromised mitochondrial energy metabolism in skeletal muscle. Other studies have shown improvements in endothelial function and reductions in markers of oxidative stress, suggesting a potential benefit for mitochondrial health.

However, while there is a scientific basis and some clinical evidence supporting the use of PLC for mitochondrial support, the overall strength and consistency of the evidence is moderate. Most studies focus on specific disease states rather than general mitochondrial health, and further research is needed to clarify its efficacy and optimal use for broader mitochondrial support.

More about Propionyl-L-Carnitine
More about Mitochondria

Other ingredients that support Mitochondria

1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
7-Keto-DHEA
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Algae
Alpha polylactate
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
apigenin
ashitaba
ashwagandha
Beef liver
berry
beta-hydroxybutyrate
black ginger
bovine liver
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
capsiate
capsinoids
cardarine
cardiolipin
catechins
centrophenoxine
chocolate
cistanche
citicoline
cocarboxylase
Coenzyme A
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine
creatine monohydrate
cyanidin
d-alpha tocopherol
D-Ribose
dihydrolipoic acid
electrolytes blend (proprietary)
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
fatty acids
fisetin
fish
fish oil
flavin mononucleotide
flavones
flavonols
fruit and vegetable blend (proprietary)
fucoxanthin
fulvic acid
fungus
gamma-glutamylcysteine
ganoderma
geranylgeraniol
Ginsenosides
glucose
Glutathione
glycerophosphocholine (GPC)
goji berry
gooseberry
grape
greens blend (proprietary)
guanidinopropionic acid (GPA )
Haematococcus pluvialis
herbal blend (proprietary)
hesperetin
Honokiol
Idebenone
inosine
Kaempferide
Kaempferol
ketone salts
knotweed
krill oil
l-carnitine
L-carnosine
L-citrulline
L-glutathione
L-glycine
L-taurine
Lentinula edodes mycelia
lingzhi
linoleic acid (LA)
lipids
liquid liver fractions
luteolin
magnesium
maitake mushroom
malic acid
manganese
maqui berry
Marine fat
Marine lipid
Matcha
medium chain triglycerides (MCT)
Melatonin
Methoxy-substituted benzoquinones
Methylxanthine
Moringa
Mushroom
Myricetin
NADH
Nannochloropsis
Naringenin
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
Nobiletin
oleanolic acid
Oleoyl-phosphatidylethanolamine
oxaloacetic acid
oxidase
pantethine
pantothenic acid (vitamin B5)
paraxanthine
phenolic compounds
phosphatidylcholine
Phosphatidylethanolamine
Phosphocreatine
Phytoplankton
Polydatin
polyphenols
Propionyl-L-Carnitine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
pyrroloquinoline quinone
pyruvate
quercetin
quinoa
quinone
resveratrol
Rhodiola
riboflavin (vitamin B2)
ribose
Ribose-l-cysteine
Rosarin
rosavins
rosemary
Salidroside
Schisandrins
selenium
Selenocysteine
Shilajit
spinach
Stilbenoid
strawberry
succinic acid
Sulforaphane
sulforaphane glucosinolate
Taxifolin
Tetradecylthioacetic acid
Thiamin (vitamin B1)
thyroid substance
tocotrienols
trace minerals
Trans-geranylgeraniol
Trans-pterostilbene
Triacetyluridine
tributyrin
Turkey tail mushroom
ubiquinol
Uridine
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
Watermelon
Withanolides
β-nicotinamide mononucleotide (NMN)

Other body systems supported by Propionyl-L-Carnitine

Arteries
Blood
Brain
Circulatory System
Heart
Mitochondria
Muscles
Nerves
Reproductive System

Products containing Propionyl-L-Carnitine

We currently have no products on Vitabase that contain this ingredient.