Pyrroloquinoline quinone disodium salt (PQQ) is supported by a moderate level of scientific evidence as a supplement to support mitochondrial health. PQQ is a redox cofactor discovered in bacteria and is present in trace amounts in various foods. Preclinical studies have shown that PQQ can stimulate mitochondrial biogenesis, the process by which new mitochondria are formed in cells, primarily through activation of signaling pathways such as PGC-1α and CREB.¹ Animal studies have demonstrated improved mitochondrial function, enhanced energy metabolism, and neuroprotective effects when PQQ is administered.² In human clinical trials, PQQ supplementation (10-20 mg/day) has been associated with improved markers of mitochondrial function, reduced oxidative stress, and subjective improvements in fatigue and cognitive performance.³ However, these studies are limited in size and duration, and more research is needed to confirm long-term benefits and optimal dosing. PQQ is not considered an essential vitamin but is regarded as a novel biofactor with potential health benefits. While there is no established traditional use for PQQ in supporting mitochondria, the current scientific literature suggests a plausible mechanism and some supportive data for its role in mitochondrial health.