Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Resveratrol is a polyphenolic compound found in grapes, berries, and peanuts, and has been studied for its effects on mitochondrial function. Scientific interest in resveratrol’s impact on mitochondria is largely based on preclinical (animal and cell-based) studies suggesting that it can activate sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK), which are pathways implicated in mitochondrial biogenesis and function. These pathways are associated with improved energy metabolism, increased mitochondrial number, and better mitochondrial efficiency. Animal studies have shown that resveratrol supplementation can enhance mitochondrial function and protect against mitochondrial dysfunction in various models of metabolic and neurodegenerative diseases.

However, clinical evidence in humans is less robust. Some small trials have reported mild improvements in markers of mitochondrial function, insulin sensitivity, and muscle metabolism with resveratrol supplementation, but results are inconsistent and often limited by small sample sizes and short durations. Systematic reviews and meta-analyses generally conclude that while resveratrol shows promise for supporting mitochondrial health, more high-quality human trials are needed to confirm its efficacy and optimal dosing.

Overall, there is scientific rationale and preliminary evidence supporting the use of resveratrol for mitochondrial health, but the strength of evidence is moderate (3/5) due to a lack of large, well-controlled human studies. Resveratrol is not a traditional remedy for mitochondrial issues, and its use in this context is a product of recent scientific investigation.

More about resveratrol
More about Mitochondria

Other ingredients that support Mitochondria

Other body systems supported by resveratrol

Products containing resveratrol

Vitabase Active Woman's Multi
Thorne Advanced Nutrients Multivitamin
Designs For Health ArthroSoothe™
Designs For Health ArthroSoothe™ Supreme
Pure Encapsulations Balanced Immune
Designs For Health BioFizz® Immune
Designs For Health CellGuard-NR 60 Capsules
Designs For Health FemGuard+Balance™
Designs For Health Inflammatone™
Designs For Health Inflammatone™
Klean Athlete Klean Multivitamin ™
Thorne L-Arginine Plus Perfusia Plus
Pure Encapsulations Memory Pro
Pure Encapsulations Memory Pro
Pure Encapsulations Metabolic Xtra
Douglas Laboratories Methlyated Resveratrol Plus
Pure Encapsulations Mitochondria-ATP
Designs For Health Mitochondrial NRG™
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Thorne PolyResveratrol-SR
Designs For Health Primal Multi™
Pure Encapsulations Renual
Pure Encapsulations ResCu-SR®
Thorne ResveraCel
Pure Encapsulations Resveratrol
Pure Encapsulations Resveratrol
Douglas Laboratories Resveratrol
Pure Encapsulations Resveratrol Extra
Pure Encapsulations Resveratrol Extra
Designs For Health Resveratrol Supreme
Integrative Therapeutics Resveratrol Ultra HP 175mg
Pure Encapsulations Resveratrol VESIsorb®
Pure Encapsulations RevitalAge™ Ultra
Designs For Health Ultimate Antiox Full Spectrum
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Pure Encapsulations Ultra Pure Pack
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Vitabase Women's Support