Evidence supporting the use of: Resveratrol analogue
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Resveratrol analogues are used to support mitochondrial function primarily based on scientific research, though the evidence is largely preclinical and emerging. Resveratrol, a polyphenolic compound found in foods like grapes and berries, and its analogues have drawn attention due to their potential to activate sirtuin 1 (SIRT1), a protein involved in cellular energy metabolism and mitochondrial biogenesis. Laboratory studies and some animal models suggest that resveratrol and certain analogues can stimulate the production of new mitochondria, enhance mitochondrial function, and improve cellular energy efficiency. These effects are thought to occur through activation of the SIRT1/PGC-1α pathway, which is central to mitochondrial biogenesis and metabolic regulation.
Despite these promising mechanistic findings, robust clinical evidence in humans remains limited. Some small-scale human studies have shown improvements in markers of mitochondrial function and metabolic health, but results are inconsistent and often use high doses or specific analogues not widely available as supplements. The majority of supportive evidence comes from cell culture and rodent studies, not large-scale, long-term clinical trials. Therefore, while the rationale for using resveratrol analogues to support mitochondrial health is scientifically grounded, the strength of clinical evidence is moderate at best and warrants further investigation.
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts
Other body systems supported by Resveratrol analogue
ArteriesBlood
Brain
Circulatory System
Heart
Mitochondria
Skin