Evidence supporting the use of: Rhodiola
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Rhodiola rosea is an adaptogenic herb traditionally used for enhancing physical and mental performance, particularly in Eastern Europe and Asia. In recent years, scientific interest has grown regarding its potential to support mitochondrial function. Several in vitro and animal studies suggest that compounds in rhodiola, such as salidroside and rosavin, can promote mitochondrial biogenesis, improve mitochondrial energy metabolism, and protect mitochondria from oxidative stress. For example, a 2015 study in Phytomedicine found that salidroside increased mitochondrial biogenesis markers in skeletal muscle of mice. Other research indicates rhodiola extracts can enhance ATP production and reduce reactive oxygen species in cell models.
However, direct evidence in humans is limited. While some clinical trials show rhodiola supplementation may reduce fatigue and improve exercise performance, these effects are not always directly linked to measured changes in mitochondrial function. The mechanistic data largely come from cell or animal models, with only indirect support in human studies. Overall, while there is promising preclinical evidence that rhodiola may support mitochondrial health, more robust human research is needed to confirm these effects and their clinical relevance.
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts
Other body systems supported by rhodiola
Adrenal CortexAdrenal Glands
Adrenal Medulla
Brain
Cortisol
Dopamine
Glandular System
Hypothalamus
Immune System
Mitochondria
Nerves
Serotonin
Sympathetic Nervous System
Products containing rhodiola
Douglas Laboratories
AdrenoMend™
Designs For Health
Adrenotone™
Designs For Health
Adrenotone™
Metagenics
Adreset
Metagenics
Adreset
Pure Encapsulations
CarbCrave Complex
Pure Encapsulations
Cortisol Calm
Pure Encapsulations
Cortisol Calm
Designs For Health
CraveArrest™
Douglas Laboratories
Cysto Renew ®
Pure Encapsulations
DopaPlus
Pure Encapsulations
Emotional Wellness
Pure Encapsulations
Emotional Wellness
Integrative Therapeutics
HPA Adapt
Designs For Health
Mito-PQQ™
Thorne
Rhodiola
Pure Encapsulations
Rhodiola Rosea
Pure Encapsulations
Rhodiola Rosea
Metagenics
Thyrosol
Pure Encapsulations
Women's Nutrients