Evidence supporting the use of: Rhodiola
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rhodiola rosea is an adaptogenic herb traditionally used for enhancing physical and mental performance, particularly in Eastern Europe and Asia. In recent years, scientific interest has grown regarding its potential to support mitochondrial function. Several in vitro and animal studies suggest that compounds in rhodiola, such as salidroside and rosavin, can promote mitochondrial biogenesis, improve mitochondrial energy metabolism, and protect mitochondria from oxidative stress. For example, a 2015 study in Phytomedicine found that salidroside increased mitochondrial biogenesis markers in skeletal muscle of mice. Other research indicates rhodiola extracts can enhance ATP production and reduce reactive oxygen species in cell models.

However, direct evidence in humans is limited. While some clinical trials show rhodiola supplementation may reduce fatigue and improve exercise performance, these effects are not always directly linked to measured changes in mitochondrial function. The mechanistic data largely come from cell or animal models, with only indirect support in human studies. Overall, while there is promising preclinical evidence that rhodiola may support mitochondrial health, more robust human research is needed to confirm these effects and their clinical relevance.

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