Evidence supporting the use of: Rhodiola crenulata
For the body system: Mitochondria

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rhodiola crenulata is an adaptogenic herb traditionally used in Asia for enhancing stamina and combating fatigue. Recent scientific interest has focused on its potential to support mitochondrial function, which is central to cellular energy production. Several in vitro and animal studies have indicated that Rhodiola extracts, often standardized to salidroside and rosavin content, may enhance mitochondrial biogenesis and improve mitochondrial efficiency.

Key preclinical studies suggest that Rhodiola crenulata supplementation can upregulate genes involved in mitochondrial energy metabolism, such as PGC-1α and NRF1, and increase ATP production in skeletal muscle cells. These effects are hypothesized to occur via activation of AMPK and related energy-regulating pathways. Additionally, antioxidant properties of Rhodiola’s active compounds may help protect mitochondria from oxidative stress and dysfunction.

However, while these mechanistic findings are promising, robust clinical trials in humans are limited. The majority of human studies with Rhodiola have assessed its effects on fatigue, mood, or exercise performance, with only indirect implications for mitochondrial health. Thus, while there is a growing body of scientific evidence from laboratory models supporting Rhodiola crenulata’s role in mitochondrial support, direct clinical validation in humans remains preliminary.

More about Rhodiola crenulata
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Products containing Rhodiola crenulata

We currently have no products on Vitabase that contain this ingredient.