Evidence supporting the use of: Rhodola crenulata
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Rhodiola crenulata has been used traditionally in Tibetan and Chinese medicine as an adaptogen to enhance physical endurance and combat fatigue. More recently, scientific studies have investigated its effects on cellular energy metabolism, particularly in relation to mitochondrial function. Preclinical studies suggest that extracts of Rhodiola, including its active compounds such as salidroside and rosavin, may enhance mitochondrial ATP production, improve mitochondrial biogenesis, and reduce oxidative stress within cells. For example, animal and cellular studies have shown that Rhodiola extracts can upregulate pathways involved in mitochondrial energy metabolism (such as AMPK and PGC-1α signaling), and protect mitochondria from oxidative damage.
However, robust clinical evidence in humans is limited. Most human studies on Rhodiola focus on its general anti-fatigue and adaptogenic effects rather than direct mitochondrial outcomes. While these effects are likely mediated through improved cellular and mitochondrial energy production, direct measurement of mitochondrial function in humans after Rhodiola crenulata supplementation is scarce. Thus, the scientific support for Rhodiola crenulata's use in supporting the "Mitochondria" body system is moderate, based primarily on mechanistic and animal data, with indirect evidence from human studies on energy and fatigue.
Overall, while there is promising scientific rationale and some supporting data, more rigorous clinical trials are needed to confirm the efficacy and mechanisms of Rhodiola crenulata in directly supporting mitochondrial health in humans.
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