Evidence supporting the use of: Rosavins (mixed)
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Rosavins are a group of phenylpropanoid glycosides found primarily in the plant Rhodiola rosea, commonly known as "golden root" or "arctic root." These compounds, including rosavin, rosarin, and rosin, are believed to contribute to the adaptogenic properties of Rhodiola. Scientific studies have suggested that Rhodiola extract, standardized to contain rosavins, may support mitochondrial function. This is based on both animal and limited human studies showing improved cellular energy metabolism, increased ATP production, and enhancement of mitochondrial resilience to stress. For example, some preclinical research demonstrates that Rhodiola extract can upregulate mitochondrial biogenesis and protect mitochondria from oxidative damage through activation of pathways such as AMPK and PGC-1α. Additionally, small clinical trials have reported improvements in fatigue, physical performance, and stress adaptation—effects thought to be mediated, in part, by mitochondrial support.
However, it is important to note that most research has been conducted on whole Rhodiola extracts rather than isolated rosavins, making it difficult to attribute the benefits solely to rosavins. The overall evidence base is promising but not definitive, with more high-quality human studies needed to establish the efficacy and mechanisms of rosavins in mitochondrial support. Thus, the use of mixed rosavins for mitochondrial health is supported by preliminary scientific evidence, but further research is warranted.
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts
Other body systems supported by Rosavins (mixed)
Adrenal GlandsBrain
Cortisol
Dopamine
Glandular System
Heart
Hypothalamus
Immune System
Mitochondria
Nerves
Parasympathetic Nervous System
Sympathetic Nervous System