Evidence supporting the use of: Schisandrins
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Schisandrins are bioactive lignans found in the fruit of Schisandra chinensis, a plant used in traditional Chinese medicine. Recent scientific research has provided evidence that Schisandrins can support mitochondrial function. Preclinical studies—primarily in vitro (cell culture) and animal models—demonstrate that Schisandrins, particularly Schisandrin B, enhance mitochondrial biogenesis, improve mitochondrial respiratory function, and protect against oxidative stress-induced mitochondrial damage. Mechanistic studies suggest Schisandrins may activate signaling pathways such as Nrf2 and PGC-1α, which are vital for mitochondrial health and cellular antioxidant defenses.
For example, in rodent models, Schisandrin B has been shown to increase ATP production, reduce mitochondrial membrane potential loss, and decrease markers of oxidative stress. Additionally, Schisandrins have demonstrated the capacity to protect mitochondria from toxin-induced injury and to support energy metabolism in various cell types. However, most evidence to date comes from laboratory and animal studies, with few clinical trials in humans directly assessing mitochondrial outcomes. Therefore, while there is a growing body of scientific evidence supporting the use of Schisandrins for mitochondrial support, more high-quality clinical research is needed to confirm these effects in humans.
References: - Szeto, YT. et al. (2011). Schisandrin B enhances mitochondrial glutathione antioxidant status in H9c2 cells and rat hearts. Biochimica et Biophysica Acta. - Panossian, A. & Wikman, G. (2008). Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine. Journal of Ethnopharmacology.
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts