Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sulforaphane glucosinolate (SGS) is a precursor to sulforaphane, a bioactive compound found in cruciferous vegetables such as broccoli. Scientific research has demonstrated that sulforaphane can activate the Nrf2 pathway, a key regulator of cellular antioxidant responses. Activation of Nrf2 leads to upregulation of genes involved in cellular defense mechanisms, including those protecting mitochondrial function and reducing oxidative stress. Mitochondria, as the primary producers of cellular energy, are particularly susceptible to oxidative damage. Preclinical studies (in vitro and animal models) have shown that sulforaphane supplementation can enhance mitochondrial biogenesis, improve mitochondrial function, and confer protection against mitochondrial toxins. For example, sulforaphane has been observed to attenuate mitochondrial dysfunction in models of neurodegenerative diseases and metabolic disorders by modulating oxidative stress and inflammation. However, while mechanistic and animal studies provide promising evidence for sulforaphane’s support of mitochondrial health, robust clinical trials in humans are limited. Most human research has focused on general antioxidant effects, detoxification, and chronic disease risk rather than direct measures of mitochondrial function. As such, the current scientific evidence supporting the use of sulforaphane glucosinolate for mitochondrial support is moderate but not definitive. Further human studies are needed to confirm these benefits in clinical settings.

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Thorne Crucera-SGS