Evidence supporting the use of: Tea Polyphenol
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Tea polyphenols—primarily catechins found in green tea, such as epigallocatechin gallate (EGCG)—have been studied for their effects on mitochondrial function. Several in vitro and animal studies suggest that tea polyphenols can enhance mitochondrial biogenesis, improve mitochondrial efficiency, and protect mitochondria from oxidative stress. These benefits appear to be mediated by activation of pathways such as AMPK and PGC-1α, which are central regulators of mitochondrial health and energy metabolism. Additionally, tea polyphenols have demonstrated antioxidant properties that can reduce mitochondrial damage from reactive oxygen species (ROS).

For example, a 2010 study in the journal Biochimica et Biophysica Acta reported that EGCG can stimulate mitochondrial biogenesis in cultured cells. Other animal studies have shown that green tea extract supplementation can increase mitochondrial content and function in skeletal muscle and brain tissue. However, evidence in human studies is more limited and mostly indirect, often focusing on metabolic markers rather than direct assessments of mitochondrial function.

In summary, while preclinical research supports a beneficial role for tea polyphenols in supporting mitochondrial health, direct clinical evidence in humans remains limited. The evidence base is promising but not yet definitive, warranting a moderate evidence rating.

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Products containing Tea Polyphenol

We currently have no products on Vitabase that contain this ingredient.