Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trans-pterostilbene is a naturally occurring polyphenol structurally similar to resveratrol, found in blueberries and Pterocarpus marsupium. It has attracted interest for its potential mitochondrial benefits, primarily based on preclinical research. Several animal and cell culture studies suggest that pterostilbene may enhance mitochondrial biogenesis and function by activating pathways such as SIRT1 and PGC-1α, which are key regulators of mitochondrial health (Wang et al., 2020). These pathways are associated with improved energy metabolism and protection against oxidative stress. Additionally, pterostilbene exhibits antioxidant properties, which may indirectly support mitochondrial integrity by reducing damage from reactive oxygen species. Some studies in rodents have demonstrated that pterostilbene supplementation can mitigate mitochondrial dysfunction in models of metabolic syndrome and neurodegenerative diseases. However, direct human evidence for mitochondrial support is lacking; most clinical trials focus on its effects on blood glucose, lipid metabolism, and cognitive function rather than direct measurement of mitochondrial endpoints. In summary, while preclinical data provide a mechanistic rationale for trans-pterostilbene’s role in supporting mitochondria, there is insufficient high-quality human evidence to robustly validate these effects. Thus, its use for mitochondrial health is scientifically plausible but not yet strongly substantiated in humans.

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