Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Tributyrin is a triglyceride form of butyric acid, a short-chain fatty acid (SCFA) produced naturally in the gut by microbial fermentation of dietary fibers. Its use to support mitochondrial function is grounded in emerging scientific evidence, though the data is not yet robust. Butyrate, the active moiety released from tributyrin, has been shown in cell culture and animal studies to enhance mitochondrial biogenesis, improve cellular energy metabolism, and protect against oxidative stress. These effects are believed to be mediated through the activation of PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) and by acting as a histone deacetylase (HDAC) inhibitor, which influences gene expression related to mitochondrial function.

Preclinical studies suggest that butyrate can improve mitochondrial respiration and ATP production in various tissues. There is also some evidence that butyrate and its derivatives, like tributyrin, can mitigate mitochondrial dysfunction in models of neurodegenerative disease and metabolic disorders. However, direct clinical studies in humans using tributyrin for mitochondrial support are limited, and most evidence comes from animal or in vitro studies. Thus, while the scientific rationale exists and preliminary data are promising, more research is needed to firmly establish its efficacy and safety for mitochondrial support in humans.

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Designs For Health Tri-Butyrin Supreme™