Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Urolithin A is a metabolite produced by gut microbiota from ellagitannins, compounds found in foods such as pomegranates, berries, and walnuts. Its primary interest in supporting mitochondrial function comes from preclinical and early clinical studies demonstrating its capacity to induce mitophagy, a process by which damaged mitochondria are selectively degraded and recycled. Animal studies have shown that Urolithin A supplementation can improve mitochondrial health, increase muscle function, and enhance endurance by promoting the renewal and efficiency of mitochondria. A pivotal human trial published in Nature Metabolism (2019) reported that oral supplementation of Urolithin A was safe and resulted in molecular signatures associated with improved mitochondrial function in elderly subjects. While these results are promising, the evidence in humans is still emerging and consists mainly of small, short-term studies, often funded by commercial interests. There are no large-scale, long-term clinical trials yet demonstrating clear clinical benefits in mitochondrial-related diseases or aging in humans. In summary, the use of Urolithin A to support mitochondrial health is grounded in mechanistic research and early human studies suggesting biological activity. However, larger and more rigorous clinical trials are needed to establish its efficacy and safety for widespread use. The current level of evidence is moderate, justifying a rating of 3 out of 5.

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Pure Encapsulations Renual