Evidence supporting the use of: Vitamin B1
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Vitamin B1, also known as thiamine, is scientifically validated to support mitochondrial function. Thiamine acts as a vital coenzyme for several enzymes involved in mitochondrial energy metabolism, particularly in carbohydrate metabolism. Specifically, thiamine pyrophosphate (TPP), its active form, is an essential cofactor for the pyruvate dehydrogenase complex and alpha-ketoglutarate dehydrogenase—both critical enzymes in the citric acid (Krebs) cycle. The citric acid cycle is central to mitochondrial ATP production. Thiamine deficiency leads to impaired mitochondrial energy generation and is clinically associated with disorders such as beriberi and Wernicke-Korsakoff syndrome, where mitochondrial dysfunction is a prominent feature.
Numerous animal and human studies have demonstrated that inadequate thiamine impairs mitochondrial metabolism, while supplementation restores function. For example, research published in Biochimica et Biophysica Acta and Journal of Neuroscience Research details how thiamine repletion reverses mitochondrial deficits. Furthermore, studies suggest potential benefits of thiamine supplementation in conditions characterized by mitochondrial dysfunction, such as heart failure, diabetes, and certain neurodegenerative diseases. However, while the biochemical role is well-established, direct clinical trials targeting mitochondrial diseases are limited. Overall, thiamine's role in mitochondrial biochemistry is well-supported, justifying its use to support this body system.
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts
Other body systems supported by Vitamin B1
AcetylcholineBlood
Brain
Circulatory System
Digestive System
Gastrointestinal Tract
Heart
Liver
Mitochondria
Muscles
Nerves
Evidence supporting the use of: Vitamin B1
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Vitamin B1, also known as thiamine, is scientifically validated to support mitochondrial function. Thiamine acts as a vital coenzyme for several enzymes involved in mitochondrial energy metabolism, particularly in carbohydrate metabolism. Specifically, thiamine pyrophosphate (TPP), its active form, is an essential cofactor for the pyruvate dehydrogenase complex and alpha-ketoglutarate dehydrogenase—both critical enzymes in the citric acid (Krebs) cycle. The citric acid cycle is central to mitochondrial ATP production. Thiamine deficiency leads to impaired mitochondrial energy generation and is clinically associated with disorders such as beriberi and Wernicke-Korsakoff syndrome, where mitochondrial dysfunction is a prominent feature.
Numerous animal and human studies have demonstrated that inadequate thiamine impairs mitochondrial metabolism, while supplementation restores function. For example, research published in Biochimica et Biophysica Acta and Journal of Neuroscience Research details how thiamine repletion reverses mitochondrial deficits. Furthermore, studies suggest potential benefits of thiamine supplementation in conditions characterized by mitochondrial dysfunction, such as heart failure, diabetes, and certain neurodegenerative diseases. However, while the biochemical role is well-established, direct clinical trials targeting mitochondrial diseases are limited. Overall, thiamine's role in mitochondrial biochemistry is well-supported, justifying its use to support this body system.
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts
Other body systems supported by Vitamin B1
AcetylcholineBlood
Brain
Circulatory System
Digestive System
Gastrointestinal Tract
Heart
Liver
Mitochondria
Muscles
Nerves