Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Benfotiamine is a synthetic, fat-soluble derivative of thiamine (vitamin B1) that has attracted attention for its bioavailability and potential effects on cellular health. Thiamine is an essential cofactor for enzymes involved in mitochondrial energy metabolism, especially in the pyruvate dehydrogenase complex and the Krebs cycle, which are crucial for ATP production. Deficiency in thiamine can lead to impaired mitochondrial function and decreased cellular energy.

Scientific studies show that benfotiamine can increase blood and tissue thiamine levels more effectively than standard thiamine. However, direct evidence that benfotiamine supplementation improves mitochondrial function in healthy individuals is limited. Most research focuses on its effects in pathological states, such as diabetic complications and neuropathy, where oxidative stress and mitochondrial dysfunction are factors. Some animal and cell studies suggest protective effects of benfotiamine on mitochondrial function under stress conditions, but robust clinical trials in humans specifically targeting mitochondrial health are lacking.

Therefore, while there is a scientific rationale for thiamine (and thus benfotiamine) supporting mitochondrial energy metabolism, and some early research hints at benefits in disease models, the level of direct scientific evidence for routine mitochondrial support is modest. The rating reflects limited but plausible evidence, especially outside of clear deficiency states.

More about Vitamin B1 (benfotiamine)
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by Vitamin B1 (benfotiamine)

Blood
Brain
Capillaries
Circulatory System
Heart
Kidneys
Mitochondria
Nerves

Products containing Vitamin B1 (benfotiamine)

We currently have no products on Vitabase that contain this ingredient.