Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Thiamin (Vitamin B1) plays a crucial role in mitochondrial function, with its use supported by scientific evidence. Thiamin is an essential coenzyme for several enzymes involved in carbohydrate metabolism, most notably pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, both of which are key components of the mitochondrial citric acid (Krebs) cycle. These enzymes help convert glucose into ATP, the primary energy currency of cells, thereby directly supporting mitochondrial energy production.

Deficiency of thiamin impairs mitochondrial function and energy metabolism, leading to conditions such as beriberi and Wernicke-Korsakoff syndrome, both of which are characterized by neurological and cardiovascular symptoms due to poor cellular energy production. Numerous scientific studies have demonstrated that thiamin supplementation restores mitochondrial enzyme activity and improves cellular energy status, particularly in individuals with marginal thiamin status or increased requirements (e.g., chronic alcohol use, certain metabolic disorders).

While thiamin supplementation is most critical in deficiency states, there is also emerging research suggesting potential benefits in mitochondrial dysfunction associated with neurodegenerative diseases and diabetes, though more clinical trials are needed to confirm efficacy in these contexts. Overall, the use of thiamin to support mitochondrial function is scientifically validated, particularly in the prevention and treatment of deficiency-related disorders.

More about Vitamin B1 (thiamin disulfide)
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by Vitamin B1 (thiamin disulfide)

Brain
Circulatory System
Digestive System
Gastrointestinal Tract
Heart
Mitochondria
Muscles
Nerves
Small Intestines

Products containing Vitamin B1 (thiamin disulfide)

We currently have no products on Vitabase that contain this ingredient.