Evidence supporting the use of: Vitamin B1 (thiamin pyrophosphate)
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Vitamin B1, in its active form thiamin pyrophosphate (TPP), is scientifically validated as essential for mitochondrial function. TPP acts as a coenzyme for several critical enzymes in carbohydrate metabolism, notably pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, which are integral to the citric acid (Krebs) cycle within mitochondria. These enzymes catalyze reactions that generate ATP, the cell’s main energy currency. Deficiency of thiamin impairs mitochondrial ATP production, leading to energy deficits in tissues with high metabolic demands, such as the nervous system and muscles.
Clinical and experimental evidence demonstrates that thiamin deficiency leads to mitochondrial dysfunction, manifesting in disorders like beriberi and Wernicke-Korsakoff syndrome. Supplementation restores enzyme function and mitochondrial energy production. Additionally, cellular and animal studies show that thiamin supplementation can improve mitochondrial metabolism under conditions of deficiency or metabolic stress. However, in individuals with adequate dietary thiamin, further supplementation has limited evidence for enhancing mitochondrial function beyond normal physiological needs.
In summary, there is strong scientific evidence that thiamin (as TPP) is necessary for core mitochondrial processes and that supplementation is effective in deficiency states. Its role in supporting mitochondrial health is well-established biochemically and clinically, justifying its use in this context.
More about Vitamin B1 (thiamin pyrophosphate)
More about Mitochondria
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts
Other body systems supported by Vitamin B1 (thiamin pyrophosphate)
BrainCirculatory System
Digestive System
Gastrointestinal Tract
Heart
Immune System
Mitochondria
Muscles
Nerves
Evidence supporting the use of: Vitamin B1 (thiamin pyrophosphate)
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Vitamin B1, in its active form thiamin pyrophosphate (TPP), is scientifically validated as essential for mitochondrial function. TPP acts as a coenzyme for several critical enzymes in carbohydrate metabolism, notably pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, which are integral to the citric acid (Krebs) cycle within mitochondria. These enzymes catalyze reactions that generate ATP, the cell’s main energy currency. Deficiency of thiamin impairs mitochondrial ATP production, leading to energy deficits in tissues with high metabolic demands, such as the nervous system and muscles.
Clinical and experimental evidence demonstrates that thiamin deficiency leads to mitochondrial dysfunction, manifesting in disorders like beriberi and Wernicke-Korsakoff syndrome. Supplementation restores enzyme function and mitochondrial energy production. Additionally, cellular and animal studies show that thiamin supplementation can improve mitochondrial metabolism under conditions of deficiency or metabolic stress. However, in individuals with adequate dietary thiamin, further supplementation has limited evidence for enhancing mitochondrial function beyond normal physiological needs.
In summary, there is strong scientific evidence that thiamin (as TPP) is necessary for core mitochondrial processes and that supplementation is effective in deficiency states. Its role in supporting mitochondrial health is well-established biochemically and clinically, justifying its use in this context.
More about Vitamin B1 (thiamin pyrophosphate)
More about Mitochondria
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts
Other body systems supported by Vitamin B1 (thiamin pyrophosphate)
BrainCirculatory System
Digestive System
Gastrointestinal Tract
Heart
Immune System
Mitochondria
Muscles
Nerves