Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B1, also known as thiamine hydrochloride, has strong scientific backing for its role in supporting mitochondrial function. Thiamine is an essential cofactor for several mitochondrial enzymes, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, both of which are critical for cellular energy (ATP) production via the Krebs cycle. Deficiency in thiamine impairs these enzymatic processes, resulting in compromised mitochondrial energy metabolism and leading to clinical syndromes such as beriberi and Wernicke-Korsakoff syndrome, which are characterized by neurological and cardiac symptoms due to impaired energy metabolism.

Research has demonstrated that thiamine supplementation can restore mitochondrial function in individuals with deficiency and has been explored in the context of inherited mitochondrial disorders as well as acquired mitochondrial dysfunction, such as that seen in diabetes and neurodegenerative diseases. Animal and human studies alike support the idea that adequate thiamine status is essential for optimal mitochondrial health and function. However, in individuals with normal thiamine status, additional supplementation has not been shown to further enhance mitochondrial activity beyond baseline needs. In summary, the scientific evidence is robust for thiamine’s necessity in mitochondrial function, particularly in deficiency states.

More about Vitamin B1 (thiamine hydrochloride)
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by Vitamin B1 (thiamine hydrochloride)

Blood
Brain
Circulatory System
Digestive System
Gastrointestinal Tract
Heart
Intestinal System
Mitochondria
Muscles
Nerves
Small Intestines

Products containing Vitamin B1 (thiamine hydrochloride)

We currently have no products on Vitabase that contain this ingredient.