Evidence supporting the use of: Vitamin B1 (thiamine mononitrate)
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Vitamin B1, also known as thiamine (often in the supplemental form thiamine mononitrate), is scientifically validated as essential for mitochondrial function. Thiamine acts as a critical cofactor for several mitochondrial enzymes involved in carbohydrate metabolism, most notably pyruvate dehydrogenase and α-ketoglutarate dehydrogenase, both of which are essential for the Krebs (citric acid) cycle. This cycle is fundamental for the production of ATP—the main energy currency of the cell—within the mitochondria. Deficiency in thiamine leads to impaired mitochondrial energy production, and this is clinically evident in disorders such as beriberi and Wernicke-Korsakoff syndrome, where neurological and cardiovascular symptoms can be traced to inadequate cellular energy production.
There is robust experimental and clinical evidence that thiamine supplementation can restore or support mitochondrial function in cases of deficiency. Studies in both animals and humans have shown that thiamine deficiency impairs mitochondrial respiration, and that supplementation reverses these effects. While supplementation beyond physiological needs in healthy individuals is not generally shown to enhance mitochondrial function, in states of deficiency or increased demand (such as certain metabolic disorders, chronic alcoholism, or specific inherited mitochondrial diseases), thiamine is a critical intervention. Thus, its use to support the mitochondrial system is based on well-established biochemical and clinical principles.
More about Vitamin B1 (thiamine mononitrate)
More about Mitochondria
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts
Other body systems supported by Vitamin B1 (thiamine mononitrate)
BloodBrain
Circulatory System
Digestive System
Gastrointestinal Tract
Heart
Mitochondria
Muscles
Nerves
Small Intestines