Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B12, specifically in its coenzyme form adenosylcobalamin, plays a scientifically validated role in mitochondrial function. Adenosylcobalamin serves as a cofactor for the mitochondrial enzyme methylmalonyl-CoA mutase, which is crucial for the metabolism of certain amino acids and fatty acids. This enzyme catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA, an important intermediate in the Krebs cycle—a central pathway for energy production in mitochondria.

Deficiency of vitamin B12 results in the accumulation of methylmalonic acid, which can impair mitochondrial energy production and cause neurological symptoms. Clinical studies have shown that B12 deficiency can lead to mitochondrial dysfunction, manifesting as muscle weakness, fatigue, and neurodegenerative changes. Supplementation with B12 restores normal mitochondrial function in deficient individuals.

While most research relates to the prevention and correction of deficiency, rather than direct enhancement of mitochondrial performance in healthy individuals, the essential role of adenosylcobalamin in mitochondrial metabolism is well established by biochemical and clinical evidence. Therefore, the use of vitamin B12 to support mitochondrial health is scientifically justified, particularly in individuals with or at risk of deficiency.

More about Vitamin B12 (adenosylcobalamin)
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Flavin mononucleotide
Fish
Fatty acids
Fucoxanthin
Flavones
Ginsenosides
Gamma-Glutamylcysteine
glucose
Glutathione
Guanidinopropionic Acid (GPA )
Geranylgeraniol
Ketone Salts

Other body systems supported by Vitamin B12 (adenosylcobalamin)

Blood
Brain
Digestive System
Gastrointestinal Tract
Heart
Mitochondria
Nerves

Products containing Vitamin B12 (adenosylcobalamin)

We currently have no products on Vitabase that contain this ingredient.