Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B2, also known as Riboflavin (including its active form, Riboflavin 5’-phosphate), is scientifically validated as essential for mitochondrial function. Riboflavin is a critical component of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), both of which are required for electron transport in the mitochondrial respiratory chain. These coenzymes participate directly in oxidative phosphorylation, the primary process by which cells generate ATP—the energy currency of the cell. Deficiency in riboflavin impairs mitochondrial energy production, leading to symptoms such as fatigue and, in severe cases, more pronounced metabolic disturbances.

Clinical studies have demonstrated that riboflavin supplementation can support mitochondrial function, particularly in conditions where mitochondrial dysfunction is present. For example, riboflavin supplementation is an established therapy for certain mitochondrial disorders, such as multiple acyl-CoA dehydrogenase deficiency (MADD) and some forms of mitochondrial myopathy. Additionally, riboflavin is used as a preventive treatment for migraine headaches, which are believed to be associated with mitochondrial energy deficits.

While not every use of riboflavin specifically targets mitochondria in the general population, its role in the electron transport chain and cellular energy metabolism is well characterized in biomedical literature (see: Powers HJ. "Riboflavin (Vitamin B2) and health." Am J Clin Nutr. 2003;83(2): 356S–360S). Therefore, its use to support mitochondrial function is strongly scientifically justified.

More about Vitamin B2 (Riboflavin Phosphate)
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Fish
Fatty acids
glucose
Ketone Salts

Other body systems supported by Vitamin B2 (Riboflavin Phosphate)

Blood
Brain
Digestive System
Eyes
Glandular System
Immune System
Mitochondria
Nerves
Skin

Products containing Vitamin B2 (Riboflavin Phosphate)

We currently have no products on Vitabase that contain this ingredient.