Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B5, also known as pantothenic acid, is essential for mitochondrial function due to its critical role in cellular metabolism. Specifically, pantothenic acid is a precursor to coenzyme A (CoA), a vital molecule in the mitochondrial matrix that facilitates the citric acid cycle (Krebs cycle) and beta-oxidation of fatty acids—both processes that generate ATP, the primary energy currency of the cell. Deficiency in vitamin B5 can impair CoA synthesis, resulting in reduced energy production and mitochondrial dysfunction.

Scientific evidence for the necessity of vitamin B5 in mitochondrial function is robust at the biochemical level: its involvement in energy metabolism is well-characterized in textbooks and confirmed by numerous in vitro and animal studies. However, clinical studies specifically supplementing vitamin B5 to improve mitochondrial health in humans are limited. Most people obtain adequate B5 from their diet, and deficiency is rare. There is some emerging interest in using B5 supplementation in metabolic disorders, but clear clinical benefits for mitochondrial diseases or dysfunction in humans have not been consistently demonstrated.

In summary, while the mechanistic and biochemical rationale for vitamin B5 supporting mitochondrial health is strong, direct clinical evidence for supplementation beyond correcting deficiency is limited, thus meriting a moderate evidence rating.

More about Vitamin B5
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by Vitamin B5

Acetylcholine
Adrenal Cortex
Adrenal Glands
Digestive System
Hair
Mitochondria
Skin

Products containing Vitamin B5

We currently have no products on Vitabase that contain this ingredient.